10/14/20 BCAN Statement on Planned Merck BCG Production Facility to Expand Capacity, September 2020 Joint Statement about the Ongoing BCG Shortage, 11/27/19: CNBC -"Mounting drug shortages delay treatments for patients with bladder cancer", 06/19/2019 Washington Post Article on BCG Shortage, 3/25/2019 BCAN Special Update- BCG Shortage: Understanding your Treatment Options, 3/8/2019 BCG Shortage-Perspectives from Josh Meeks, 3/4/19 BCG Shortage 2019: Managing Through Treatment and Reimbursement Issues - Neal Shore, Ashish Kamat, and Jonathan Rubenstein, 3/1/2019 SWOG Now Searches for BCG Replacement, 2/19/2019 Update from the AUA, BCAN, SUO, and others, 2/12/2019 BCAN's Response to the BCG Shortage, Merck anticipates supply constraints for TICE® BCG for the foreseeable future, American Association of Clinical Urologists. BCAN Board of Directors member, Dr. Neal Shore discusses the current 2019 shortage of BCG with Dr. Ashish Kamat and Dr. Jonathan Rubenstein on video by Uro Today. Code de la santé publique. For those in whom cystectomy in unsuitable or refused, the guidelines suggest clinical trials with the use of intravesical chemotherapy when/where clinical trials are unavailable. To begin, Dr. Lerner provided context, highlighting the current status of the Bacille Calmette-Guérin (BCG) shortage as well as risk stratification and guideline recommendations. Wallis, MD, PhD, Urologic Oncology Fellow, Vanderbilt University Medical Center Contact: @WallisCJD on Twitter at the 2020 American Urological Association (AUA) Annual Meeting, Virtual Experience #AUA20, June 27- 28, 2020Related Content:Read: ASCO GU 2020: Management Strategies in the Face of the Bacillus Calmette-Guérin Shortage. Consulter le journal du jour. Même chose pour le BCG. Le vaccin BCG (du nom de ses inventeurs, Bacille de Calmette et Guérin) est le vaccin contre la tuberculose. Elle limite le risque de développer l’infection et prévient les formes graves de la tuberculose chez les jeunes enfants. Where this is not possible, dose reduction to ½ or 1/3 dose was recommended. Il s’agit d’un vaccin vivant atténué : il contient des germes vivants du bacille, modifiés afin qu’ils ne puissent plus induire la maladie. Vaccinations obligatoires et recommandées 7 2.1 Coqueluche 8 2.2 Diphtérie, tétanos, poliomyélite 10 ... 3.5 BCG 42 4. As a result of BCG shortages, a number of recommendations were made as part of a joint statement from the AUA, AACU, BCAN, SUO, LUGPA, SUO, and UCF. BCAN is deeply concerned about the current BCG shortage for treatments for bladder patients. BCG vaccine is in phase III trials in health care workers in Australia and Netherlands. SWOG Cancer Research Network research may help us fill the void. (mise à jour en septembre 2020) P.1 /12 Tableau 1 : Vaccination systématique recommandée - Résumé des notes d’information de l’OMS ... • La vaccination par le BCG est aussi recommandée pour enfants plus âgés, adolescents et adultes non-vaccinés qui sont TCT … Calendrier des vaccinations 2019 - Tableaux synoptiques 43 ... • Généralisation de la compétence vaccinale contre la grippe des pharmaciens pour la saison 2019-2020. Watch this short video with Josh Meeks and Alicia Morgans as they discuss the clinical treatment of High-Risk NMIBC in a BCG rationed era. Copyright © 2017-2019 Bladder Cancer Advocacy Network. For more information about BCG and other intravesical therapies, please visit our Intravesical Therapy page, and be sure to watch our June 2019 webinar about treatment options during the BCG shortage. On June 18th, the Washington Post released an article about the BCG Shortage, and it includes statements from patients, doctors, Merck, and the FDA. In September of 2020, BCAN, along with the American Urological Association, American Association of Clinical Urologists, Society of Urologic Oncology, Large Urology Group Practice Association and the Urology Care Foundation, released a joint statement regarding suggested strategies to help maximize the care of patients with non-muscle invasive bladder cancer. In closing, they offered a few recommendations in the scenario of no available BCG including a risk-stratified approach utilizing chemotherapy, combination chemotherapy, and radical cystectomy on the basis of risk of progression and recurrence. Toutefois, en cas d’intradermoréaction à la tuberculine négative (induration < 5 mm), la revaccination n’est plus obligatoire. In addition, he highlighted that, in July 2019, the HCPCS billing code J9030 allowed for billing for multiple uses of a single vial of BCG. In the meantime, he highlighted that BCG dose reduction may actually provide benefit as an appropriate cytokine response may be observed with very low disease, as little as 1/100th of a standard treatment dose. National shortages of BCG in recent years leading some clinics and hospitals to run out, and some to ration supplies. Les vaccinations obligatoires sont les suivantes : l’hépatite B, la diphtérie, le tétanos, la poliomyélite, et dans certains cas, la fièvre typhoïde et les antituberculeux BCG. Dr. McKiernen then discussed a variety of novel chemotherapeutic regimes including single-agent valrubicin, gemcitabine, taxanes, and electromotive or hyperthermic mitomycin and multi-agent regimes. Although there is no mandatory vaccination schedule (apart from healthcare workers who must receive the diphtheria vaccine), the healthcare service in Portugal provides a full program of free vaccinations for babies, children, and other special groups. First, the joint statement highlighted that BCG should not be used for patients with low-risk disease. Suite 610 Merck increased production of TICE BCG by more than 100 percent to enable it to be produced at the full extent of their manufacturing capacity. whether the BCG vaccine has an immune training effect. Dr. Kamat then discussed how to prioritize the utilization of limited BCG supplies. If you have any questions about this guidance, please contact BCAN either by email or by calling us at 1-888-901-2226. BCAN is a 501(c)3 non-profit organization. He highlighted that the AUA/SUO guidelines recommend offering radical cystectomy in patients with high-risk disease who have recurrent or persistence following two induction cycles of BCG. Concernant la vaccination contre la tuberculose, le BCG reste à ce jour obligatoire pour les personnels de santé. The same clinical trials group that helped establish the effectiveness of BCG may also help establish the effectiveness of a replacement. 2° Dans les écoles maternelles ; Papillomavirus, BCG... Découvrez les nouveautés du calendrier vaccinal 2019 . As always, it is important that these decisions be made after an informed discussion with the individual patient regarding their treatment options in the context of the ongoing BCG shortage. Elle permet de les protéger efficacement et durablement contre de nombreuses maladies infectieuses graves voire mortelles. The WHO does not recommend its use for prevention as of 13 April 2020. Steve Boorjian, Ashish Kamat, James McKiernan, Chad Ritch, and Dr. Lerner explored a number of treatment options. Son efficacité varie de 75 à 85 %. Elle fait toutefois l’objet d’une forte recommandation pour les enfants à risque élevé de contracter une tuberculose et reste obligatoire pour les professionnels des filières socio-sanitaires. La vaccination est obligatoire chez les nourrissons et les enfants. Click on the image below to read the full article. Bethesda, MD 20814. DÉSINTOX – Alors que onze vaccins sont désormais obligatoires pour les bébés nés depuis le 1er janvier 2018, les opposants à la vaccination restent nombreux. If you want to consider enrolling in a clinical trial as an appropriate alternative management strategy to BCG treatment alone, you can find more information on BCAN’s Clinical Trial Dashboard. L’extension à 11 vaccins obligatoires a été promulguée par la loi du 30 décembre 2017 suite à la proposition d’Agnès Buzyn, ministre des Solidarités et de la Santé de rendre obligatoires 8 vaccins supplémentaires jusqu’alors recommandés pour la petite enfance, en complément des 3 vaccins actuellement obligatoires. Not … Le vaccin contre la tuberculose n’est plus obligatoire depuis 2007. MMC is the most readily available option and Dr. Ritch discussed approaches to optimize MMC. Photo - POOL/AFP - Ian LANGSDON Encore incertaine il … Click on the image below to read the full statement. Depuis la disparition de la forme multipuncture du vaccin BCG (Monovax) en 2005, un seul vaccin BCG existe : le BCG SSI intradermique, dérivé de la souche danoise Copenhague 33. Cette vaccination n’est plus obligatoire … In patients with prior BCG failure, treatment with gemcitabine was associated with better recurrence free survival than re-induction with BCG. Sont soumis à la vaccination obligatoire par le vaccin antituberculeux BCG : A.-Les enfants de moins de six ans accueillis : 1° Dans les établissements, services et centres mentionnés à l'article L. 2324-1 ;. The panelists highlighted data showing that the BCG shortage has resulted in increased rates of recurrence and increased utilization of cystectomy, even within risk groups. More recently, a combination of cabazitaxel, gemcitabine, and cisplatin has been explored. We believe in the power of human potential and our growth is driven by exceptional talent. On November 27, 2019, CNBC ran a story about the BCG shortage, addressing production and supply and distribution challenges. La vaccination par le BCG (Bacille Calmette et Guérin) est le seul moyen de se protéger contre la tuberculose. Dr. McKiernan then discussed combination regimes starting with gemcitabine plus docetaxel. BCG : vaccin contre la tuberculose Vérifié le 01 avril 2019 - Direction de l'information légale et administrative (Premier ministre) La vaccination contre la tuberculose n'est plus obligatoire. Dimanche 29 novembre 2020. He also highlighted alternatives to BCG including intravesical chemotherapy with mitomycin C, valrubicin, gemcitabine, and nab-paclitaxel. He highlighted than the key concept was to avoid further use of BCG, particularly in the setting of a BCG shortage where we don’t want to waste BCG on patients who are unlikely to benefit. Get news and information from Bladder Cancer Advocacy Network straight to your inbox. Polish scientists are investigating [when?] C’est le cas ainsi pour de nombreuses maladies. In September 2020, BCAN, along with American Urological Association (AUA), American Association of Clinical Urologists (AACU), the Society of Urologic Oncology (SUO), the Large Urology Group Practice Association (LUGPA) and the Urology Care Foundation (UCF) issued a statement expressing concern about this ongoing shortage and its effects on the care of bladder cancer patients. To read the guidance, please click here. In somewhat of a contrast from Dr. Lerner, Dr. Kamat highlighted that the optimal maintenance approach is the SWOG/”Lamm” protocol with 6+3 approach which shows a significant benefit. In patients with intermediate-risk disease, intravesical chemotherapy should be used as a first-line treatment with an alternative chemotherapeutic agent used as second-line therapy. A la fin du XIXe siècle, les connaissances sur la tuberculose s'accumulaient rapidement. However, even with increased production, an increasing global demand is leading to supply constraints. Click below to open the newsletter in a new tab. Le début des recherches sur la tuberculose et les vaccinations. In addition, he highlighted that the duration of therapy (1 versus 3 years) appears to be more influential than dosage (1/3 versus full dose) as highlighted in data from the EORTC 30962 trial: In keeping with the guideline recommendations highlighted by Dr. Lerner, Dr. Kamat offered a summary of the recommendations for prioritizing the use of limited BCG resources including induction in high-risk patients and maintenance according to the SWOG protocol. The bacillus Calmette-Guerin, or BCG, shot has been used widely for about 100 years, with a growing appreciation for its off-target benefits. Dr. Ritch then discussed practical approaches to applying this in clinical practice. Le Premier ministre Jean Castex détaille les modalités du confinement lors d'une conférence de presse à Paris, le 29 octobre 2020. 10/14/20 – BCAN Statement on Planned Merck BCG Production Facility to Expand Capacity. He then postulated what the future may hold including a number of agents currently under investigation. Bacille Calmette-Guérin (BCG) has been a standard of care for many patients with non-muscle invasive bladder cancer for decades. Pour en savoir plus, consultez la section Changements apportés au programme de vaccination en milieu scolaire. Your success is accelerated from day one through mentorship, training, and a culture of apprenticeship. BCAN and our Scientific Advisory Board have been advised by Merck & Co., Inc., that they anticipate a limited supply of BCG in the next year. "At BCG, our purpose is fueled by our people. As discussed above, the EORTC 30962 trial showed no difference between 1/3 dose and full-dose BCG in patients with high-risk disease. AUA 2020 BCG Shortage for High-Risk NMIBC Patients, Bacille Calmette-Guérin, Seth Lerner, EORTC 30962 trial, gemcitabine versus BCG in NMIBC, alternatives to BCG including intravesical chemotherapy. Where there is sufficient supply for maintenance therapy, the joint statement recommended the use of a 1/3 dose with a one year course. Ces changements font suite à un avis du Comité sur l’immunisation du Québec et touche la vaccination en milieu scolaire. BCG vaccine is being evaluated in Greece and Poland. Dr. Boorjian then presented on the treatment of patients with BCG unresponsive disease. Information on immunization programs was collected by the Canadian Nurses Coalition on Immunization (CNCI). Version en vigueur au 01 décembre 2020. PHAC and the CNCI have worked together since July 2004 to develop this tool containing the latest provincial/territorial program information. Saint-Denis La Plaine (France) ; 2020 [consulté le 30 septembre 2020] Based on personal communication, Dr. Lerner conveyed that Merck considers the production of BCG at maximal capacity to be a priority. Patients with high-risk non-muscle invasive bladder cancer should be prioritized to receive BCG which full-strength treatment courses recommended. Click here to learn more. Certaines vaccinations sont obligatoires, d'autres recommandées. To read the full statement, please click below. La vaccination par le BCG n’est dorénavant plus exigée à l’entrée en collectivité. Historique : La découverte du BCG . BCG vaccine, vaccine against tuberculosis.The BCG vaccine is prepared from a weakened strain of Mycobacterium bovis, a bacteria closely related to M. tuberculosis, which causes the disease.The vaccine was developed over a period of 13 years, from 1908 to 1921, by French bacteriologists Albert Calmette and Camille Guérin, who named the product Bacillus Calmette-Guérin, or BCG.